Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1 Inhibition

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source : nejm.org
Raphaela Goldbach-Mansky, M.D., Natalie J. Dailey, M.D., Scott W. Canna, M.D., Ana Gelabert, M.S.N., Janet Jones, B.S.N., Benjamin I. Rubin, M.D., H. Jeffrey Kim, M.D., Carmen Brewer, Ph.D., Christopher Zalewski, M.A., Edythe Wiggs, Ph.D., Suvimol Hill, M.D., Maria L. Turner, M.D., Barbara I. Karp, M.D., Ivona Aksentijevich, M.D., Frank Pucino, Pharm.D., [...]

Incomplete and Atypical Kawasaki Disease in a Young Infant: Severe, Recalcitrant Disease Responsive to Infliximab

Matthew J. O’Connor, MD
Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia
Frank T. Saulsbury, MD
Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia, fts@virginia.edu

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This report describes a 7-week-old infant with incomplete and atypical [...]

Congenital Heart Block.

Friedman DM, Duncanson LJ, Glickstein J,  Buyon JP.
Images Paediatr Cardiol 2003;16:36-48

 

 

 

 

Abstract
Congenital heart block is a rare disorder. It has an incidence of about 1 in 22,000 live births. It may be associated with high mortality and morbidity. This should generate a high index of suspicion for early diagnosis and aggressive therapy when appropriate. The congenital [...]

NEONATAL RHEUMATIC DISEASE

Rheumatic diseases are rarely encountered in newborns and fall broadly into three groups: (a) transplacentally acquired immunological diseases such as neonatal lupus and neonatal antiphospholipid syndrome; (b) genetic conditions such as the chronic infantile neurologic cutaneous and articular (CINCA) syndrome (also known as neonatal-onset multisystem inflammatory disease – NOMID); and, (c) other miscellaneous disorders that [...]

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Milia

MILIA AND BABY ACNE
These commonly occur on the face and scalp, and consist of tiny white papules which are usually discrete.  They can however occur anywhere, and may be present at birth or appear subsequently.  They usually resolve within a few months without treatment.
Milia are inclusion cysts which contain trapped keratinised stratum corneum.  They may [...]

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Onset in the second to third day of life, mostly in term babies of lesions characterised by a central whitish to yellowish papule surrounded by a halo of erythema, mainly over the trunk but also in the limbs and face. Lesions may intensify or coalesce particularly in response to local heat. They wax and wane [...]

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